Mitotic Spindle

Mitotic spindle - The mitotic spindle is a structure of the eukaryotic cytoskeleton involved in mitosis and meiosis, often referred to as the meiotic spindle during meiosis. It consists of a bundle of microtubules joined at the ends but spread out in the middle, vaguely resembling an American football in shape.

Spindle checkpoint - The spindle checkpoint blocks the entry of a cell undergoing mitosis into anaphase until all chromosomes are properly attached to the meiotic or mitotic spindle. To achieve proper segregation, the two kinetochores on the sister chromatids must be attached to opposite spindle poles.

Centromere - The centromere is a region of a eukaryotic chromosome where the kinetochore is assembled. Thus, it is the site where spindle fibers of the mitotic spindle attach to the chromosome during mitosis.

Michael Swann - ... of Coln St Denys, Sir Michael Meredith Swann FRS (1920-1990) was a distinguished molecular and cell biologist working on the mechanisms of cell division and fertilisation. He used cell polarisation methods to understand the changes in molecular organisation of the mitotic spindle.

mitoticspindle

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